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FAK: A Key Player in Cancer Progression

Overexpression and Activation in Solid Cancers

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that plays a crucial role in cancer progression. It is overexpressed and activated in several advanced-stage solid cancers, making it a potential target for cancer therapy.

FAK Dynamics: A Complex Process

FAK dynamics is a continuous process involving coordination between focal adhesions (FAs) and the actin cytoskeleton. This process is essential for cell migration, invasion, and metastasis. Dysregulation of FAK dynamics can lead to uncontrolled cell growth and cancer progression.

FAK Reporter: Visualizing Endogenous FAK Activity

Researchers have engineered a focal adhesion kinase (FAK) reporter that can visualize endogenous FAK activity with dynamic spatiotemporal resolution. This tool allows researchers to study FAK activity in real time and to identify potential targets for cancer therapy.

FAK Activation by RAF and MEK Inhibitors

In addition to RAF inhibitors dabrafenib (GDC-0879) or vemurafenib, MEK inhibitors trametinib can also activate FAK within a couple of hours. This activation is mediated through the ERK pathway and can contribute to resistance to RAF inhibitors.

Conclusion

FAK is a key player in cancer progression and a potential target for cancer therapy. The development of FAK inhibitors and the understanding of FAK dynamics are important steps towards the development of more effective cancer treatments.